Patient experience and diagnostic odyssey

Fatigue is severe, common, and systematically underweighted

probablefinding

Fatigue is among the highest-burden symptoms in hEDS/HSD cohorts yet historically underweighted against joint and skin features. The 2017 multisystem criteria and subsequent cohort work restored it to the clinical picture.

Subtype scope	hEDS, HSD
Criteria era	international-2017
Reviewed	2026-09-16

Evidence

clinicalexpert review

Hypermobile Ehlers-Danlos syndrome (a.k.a. Ehlers-Danlos syndrome type III and Ehlers-Danlos syndrome hypermobility type): Clinical description and natural history · American Journal of Medical Genetics Part C · 2017-03 · paywalled

clinicalcohort study

Health care supply in patients with Ehlers-Danlos syndromes and generalized hypermobility spectrum disorder: a German perspective · Orphanet Journal of Rare Diseases · 2025