Management and clinical care
Local anesthetic resistance — the index's reference convergence
establishedpracticestrata convergecaution
Patients reported local-anesthetic failure for decades. Hakim and Grahame's 2005 survey found 58% of hypermobile patients reported inadequate anesthesia vs 21% of controls; a 2019 survey (n=988) found 88% vs 33%; in 2025 a randomized cross-over trial (n=135) confirmed shorter lidocaine duration in EDS patients. The arc — forum reports, structured survey, randomized confirmation — is the model this index exists to document.
| Subtype scope | all EDS types |
|---|---|
| Date | 2025 |
| Criteria era | international-2017 |
| Practice kind | procedural |
| Venues | r/ehlersdanlos, EDS and HSD Support Community (Inspire) |
| Risk note | Procedure planning should anticipate reduced local-anesthetic duration; flag the diagnosis before dental and minor surgical work. |
| Reviewed | 2026-09-16 |
Evidence
communitycross-venue pattern
Dental-procedure anesthetic failure is among the oldest recurring community reports.
clinicalcohort study
clinicalrandomized trial
registrytrial registration