Genetics and biomarkers
hEDS is the only subtype without a confirmed molecular basis
establishedfinding
All twelve other 2017 subtypes have defined causative genes. For hEDS — the most common type — no confirmed molecular basis existed through 2024, forcing purely clinical diagnosis and the strict 2017 criteria as the only gate.
| Subtype scope | hEDS |
|---|---|
| Criteria era | international-2017 |
| Reviewed | 2026-09-16 |
Evidence
clinicalconsensus statement