Comorbidities and systemic features

hEDS patients average ten alternative diagnoses before confirmation

The Global Registry survey (n=505, clinically confirmed hEDS) found a mean of 10.45 alternative diagnoses — most commonly anxiety, depression, and migraine — with functional neurological disorder and multiple sclerosis among the most-rejected labels. Post-diagnosis, participants most endorsed POTS, cervical instability, and MCAS as accurate.