Comorbidities and systemic features
GI dysmotility and autonomic features are documented comorbidity domains
probablefinding
The 2017 series and subsequent cohort work document gastrointestinal dysmotility (reflux, gastroparesis, constipation) and autonomic dysfunction (orthostatic intolerance, POTS) as leading comorbidity domains in hEDS/HSD. The German 2025 cohort shows musculoskeletal pain and joint instability as the dominant presenting manifestations.
| Subtype scope | hEDS, HSD |
|---|---|
| Criteria era | international-2017 |
| Reviewed | 2026-09-16 |
Evidence
clinicalexpert review