Diagnosis and classification

The 2017 hEDS criteria require hypermobility, systemic manifestations, and exclusion

hEDS diagnosis under the 2017 International Classification requires (1) generalized joint hypermobility by Beighton score, (2) two or more of systemic manifestations, positive family history, or musculoskeletal complications, and (3) exclusion of other connective-tissue disorders. Unlike every other subtype, hEDS has no molecular confirmation test.